BNP Paribas will provide CMC Markets with custody and settlement services for its trading activities across 11 countries.
RBC I&TS is currently two years into a four-year programme of digitally transforming its back- and middle-office services globally.
JP Morgan was the largest custodian in Australia with $778 billion in assets under custody at the end of 2017.
The moves follow the recent appointment of James Nolan as group head of strategy and merger and acquisition.
Robotics and automation has been touted to generate $20 billion in savings across the securities services industry.
Madeleine Senior, who has served as country head for almost three years, will take on a new leadership role in London.
The US bank will provide custody and investment services to Genworth’s AUD$3.5 billion investment portfolio.
The former global head of collateral management product at JP Morgan, who joined Lombard Risk in 2016, will head up the expansion.