Brand will also work alongside the heads of Luxembourg and Ireland, as the US bank looks to evolve its European strategy.
Northern Trust is currently providing accounting services for select clients that have a small portion of their assets in cryptocurrencies.
High-profile custody mandates and the implementation of new technology products helped drive second quarter revenues.
Investment services revenues of increased 8% to $3.1 billion year-on-year but remained flat over the previous quarter.
The investment from Euroclear was in response to client demands wanting access untapped liquidity pools in the bond market.
Custodians stand to benefit from using the technology for new revenue-generating products around data services.
Regulators are hoping to harmonise the safekeeping requirements for UCITS and AIFMD funds, however this could mean stricter record-keeping requirements.
A fully integrated trading, settlement and custody infrastructure for digital assets is set to launch in 2019.
Clearing members will now be able to use UK and US government treasury bills, bonds, and other approved fixed income securities as collateral.